Adhesive Dermally Applied Microarray (ADAM)
What is ADAM?
ADAM is a small adhesive device for intracutaneous drug delivery allowing rapid absorption into the bloodstream. ADAM is applied to the skin using a ready to use low cost reusable handheld applicator.
Each ADAM is individually packaged and stored at room temperature.
How does it work?
An array of over a thousand tiny drug-coated titanium micro projections is mounted on the skin-facing surface of a backing that resembles an adhesive bandage. The length of each micro projection is about 3 times the width of a human hair.
When the ADAM is applied, the micro projections penetrate the outermost layer of the epidermis (stratum corneum). The shallow depth of penetration limits the likelihood of stimulating sensory nerve endings. Interstitial fluid in the skin reconstitutes the drug and makes it available for rapid absorption.
What are the Advantages of ADAM?
Rapid Parenteral Delivery without the Needle
There are instances where a drug cannot or should not be administered orally. For example, some drugs have poor oral bioavailability. In other cases, patients may not be able to tolerate an orally administered drug. In addition, intestinal absorption following oral delivery can be slow, delaying the beneficial effects a drug may provide.
ADAM allows parenteral drug delivery without the use of a hypodermic needle. In clinical studies, less than 10% of patients reported any pain at the application site. Pharmacokinetic analysis demonstrated ~ 3-times faster absorption of zolmitriptan using ADAM compared with orally administered zolmitriptan.